Abstract:

Primary open-angle glaucoma(POAG) is one of  blindness-causing diseases. Although we have already found out multiple molecules and signaling pathways that interact with each other are involved, the exact pathogenesis that leads to the progression of POAG is poorly understood. Secreted protein, acidic and rich in cysteine (SPARC), defined as a matricellular protein, is distributed throughout the human ocular tissue. SPARC, which can modulate the synthesis of extracellular matrix (ECM) and affect cellular morphology and adhesions, plays an important role in the increase of outflow resistance in patients with POAG by modulating the morphology and structure of trabecular meshwork(TM).   (Int Rev Ophthalmol,  2015,  39:    368-371)